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DeCS
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Descriptor English:
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Myasthenia Gravis, Autoimmune, Experimental
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Descriptor Spanish:
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Miastenia Gravis Autoinmune Experimental
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Descriptor Portuguese:
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Miastenia Gravis Auto-Imune Experimental
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Synonyms English:
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Myasthenia Gravis, Experimental Autoimmune
Passive Transfer Experimental Autoimmune Myasthenia Gravis
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Tree Number:
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C10.114.656.300
C10.114.703.350
C10.668.758.725.300
C20.111.258.500.300
C20.111.258.625.350
E05.598.500.500.750
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Definition English:
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Any autoimmune animal disease model used in the study of MYASTHENIA GRAVIS. Injection with purified neuromuscular junction acetylcholine receptor (AChR) (see RECEPTORS, CHOLINERGIC) components results in a myasthenic syndrome that has acute and chronic phases. The motor endplate pathology, loss of acetylcholine receptors, presence of circulating anti-AChR antibodies, and electrophysiologic changes make this condition virtually identical to human myasthenia gravis. Passive transfer of AChR antibodies or lymphocytes from afflicted animals to normals induces passive transfer experimental autoimmune myasthenia gravis. (From Joynt, Clinical Neurology, 1997, Ch 54, p3) |
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History Note English:
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2005 (2000)
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Allowable Qualifiers English:
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Record Number:
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34209
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Unique Identifier:
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D020720
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Occurrence in VHL:
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Similar:
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DeCS SciELO LILACS LIS
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